Critical Illness-Related Corticosteroid Insufficiency in Patients With Cirrhosis and Variceal Bleeding

Background & Aims Relative adrenal insufficiency (AI) occurs in patients with cirrhosis with sepsis, but not with variceal bleeding. We evaluated adrenal function in cirrhotic patients with and without bleeding. Methods Twenty cirrhotic patients with variceal bleeding were evaluated using the sh...

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Veröffentlicht in:	Clinical gastroenterology and hepatology 2011-07, Vol.9 (7), p.595-601
Hauptverfasser:	Triantos, Christos K, Marzigie, Michel, Fede, Giuseppe, Michalaki, Marina, Giannakopoulou, Dimitra, Thomopoulos, Konstantinos, Garcovich, Matteo, Kalafateli, Maria, Chronis, Aris, Kyriazopoulou, Venetsana, Jelastopoulou, Eleni, Nikolopoulou, Vasiliki, O'Beirne, James, Burroughs, Andrew K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - deficiency Adult Aged Critical Illness Female Gastroenterology and Hepatology Gastrointestinal Hemorrhage - complications Humans Hydrocortisone - blood Liver Cirrhosis - complications Liver Disease Male Middle Aged Pituitary Stress Varices
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Zusammenfassung:	Background & Aims Relative adrenal insufficiency (AI) occurs in patients with cirrhosis with sepsis, but not with variceal bleeding. We evaluated adrenal function in cirrhotic patients with and without bleeding. Methods Twenty cirrhotic patients with variceal bleeding were evaluated using the short synacthen test (SST) and 10 using the low-dose synacthen test (LDSST) followed by SST. The control group included 60 stable cirrhotic patients, assessed by LDSST (n = 50) or SST (n = 10), and 14 healthy volunteers. AI was diagnosed using SST, based on peak cortisol levels ≤18 μg/dL in nonstressed patients or Δmax
ISSN:	1542-3565 1542-7714
DOI:	10.1016/j.cgh.2011.03.033