Severe Right Ventricular Outflow Tract Obstruction Caused by Non-Hodgkin Lymphoma: Complete Regression after One Course of Bendamustine/Rituximab Therapy

We present the case of a 67-year-old woman presenting with symptoms of predominantly right heart failure caused by cardiac tumor infiltration. Echocardiography showed almost complete obstruction, particularly of the right ventricular outflow tract. After complete diagnostic workup, treatment with on...

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Veröffentlicht in:	Journal of the American Society of Echocardiography 2011-07, Vol.24 (7), p.818.e1-818.e4
Hauptverfasser:	Konstandin, Mathias H., MD, Korosoglou, Grigorios, MD, Hosch, Waldemar, MD, Hardt, Stefan E., MD, Katus, Hugo A., MD, Mereles, Derliz, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Agents - therapeutic use B-cell non-Hodgkin lymphoma Bendamustine and rituximab Bendamustine Hydrochloride Cardiovascular Diagnosis, Differential Drug Therapy, Combination Echocardiography Female Follow-Up Studies Humans Lymphoma, B-Cell - complications Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - drug therapy Nitrogen Mustard Compounds - therapeutic use Recovery of Function - physiology Right ventricular outflow tract obstruction Rituximab Severity of Illness Index Tomography, X-Ray Computed Ventricular Function, Right - physiology Ventricular Outflow Obstruction - diagnostic imaging Ventricular Outflow Obstruction - etiology
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Zusammenfassung:	We present the case of a 67-year-old woman presenting with symptoms of predominantly right heart failure caused by cardiac tumor infiltration. Echocardiography showed almost complete obstruction, particularly of the right ventricular outflow tract. After complete diagnostic workup, treatment with only one course of bendamustine and rituximab resulted in complete resolution of the obstruction. Right ventricular outflow tract restriction due to infiltrative large B-cell lymphoma is a rare finding. Compression of the heart and great vessels, such as by mediastinal tumors, is not as rare. Prompt and accurate diagnosis by echocardiography and immediate initiation of treatment can be lifesaving.
ISSN:	0894-7317 1097-6795
DOI:	10.1016/j.echo.2010.09.005