Ultra-high resolution 17O solid-state NMR spectroscopy of biomolecules: A comprehensive spectral analysis of monosodium L-glutamate-monohydrate

Monosodium L-glutamate monohydrate, a multiple oxygen site (eight) compound, is used to demonstrate that a combination of high-resolution solid-state NMR spectroscopic techniques opens up new possibilities for (17)O as a nuclear probe of biomolecules. Eight oxygen sites have been resolved by double...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2011-07, Vol.13 (26), p.12213-12224
Hauptverfasser:	WONG, Alan, HOWES, Andy P, YATES, Jonathan R, WATTS, Anthony, ANUPOLD, Tiit, PAST, Jaan, SAMOSON, Ago, DUPREE, Ray, SMITH, Mark E
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology General and physical chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy - methods Models, Molecular Oxygen Isotopes - chemistry Quantum Theory Sensitivity and Specificity Sodium Glutamate - chemistry
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Beschreibung
Zusammenfassung:	Monosodium L-glutamate monohydrate, a multiple oxygen site (eight) compound, is used to demonstrate that a combination of high-resolution solid-state NMR spectroscopic techniques opens up new possibilities for (17)O as a nuclear probe of biomolecules. Eight oxygen sites have been resolved by double rotation (DOR) and multiple quantum (MQ) NMR experiments, despite the (17)O chemical shifts lying within a narrow shift range of
ISSN:	1463-9076 1463-9084
DOI:	10.1039/c1cp20629j