Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort

Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort

This study investigated what factors radiologists take into account when estimating emphysema severity and assessed quantitative computed tomography (CT) measurements of low attenuation areas. CT scans and spirometry were obtained on 1519 chronic obstructive pulmonary disease (COPD) subjects, 269 sm...

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Veröffentlicht in:Academic radiology 2011-06, Vol.18 (6), p.661-671
Hauptverfasser: Gietema, Hester A, Müller, Nestor L, Fauerbach, Paola V Nasute, Sharma, Sanjay, Edwards, Lisa D, Camp, Pat G, Coxson, Harvey O
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Algorithms
Analysis of Variance
Biomarkers
Case-Control Studies
Cluster Analysis
Disease Progression
Female
Forced Expiratory Volume
Humans
Longitudinal Studies
Male
Middle Aged
Pulmonary Emphysema - diagnostic imaging
Pulmonary Emphysema - physiopathology
Radiographic Image Interpretation, Computer-Assisted
Regression Analysis
Severity of Illness Index
Spirometry
Tomography, X-Ray Computed
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Zusammenfassung:This study investigated what factors radiologists take into account when estimating emphysema severity and assessed quantitative computed tomography (CT) measurements of low attenuation areas. CT scans and spirometry were obtained on 1519 chronic obstructive pulmonary disease (COPD) subjects, 269 smoker controls, and 184 nonsmoker controls from the Evaluation of COPD Longitudinally to Indentify Surrogate Endpoints (ECLIPSE) study. CT scans were analyzed using the threshold technique (%
ISSN:1878-4046
DOI:10.1016/j.acra.2011.01.011