Bioinspired Functionalization of Silica-Encapsulated Yeast Cells

Tough shell: Living yeast cells can be simultaneously silica‐encapsulated and thiol‐functionalized by polycondensation of silicic acid and (3‐mercaptopropyl)trimethoxysilane under mild conditions. Various functions such as fluorescent dyes (see picture; green: fluorescein, red: rhodamine), chemical...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-06, Vol.50 (27), p.6115-6118
Hauptverfasser:	Yang, Sung Ho, Ko, Eun Hyea, Jung, Young Hwan, Choi, Insung S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Avidin - chemistry Biocompatible Materials - chemistry biomimetic synthesis Biomimetics Biotin - chemistry Cells, Immobilized - chemistry Cells, Immobilized - cytology encapsulation layer-by-layer processes Methacrylates - chemistry Nanoparticles - chemistry Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Polymers - chemistry Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - ultrastructure Silanes - chemistry silica Silicic Acid - chemistry Sulfonic Acids - chemistry yeast cells
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Beschreibung
Zusammenfassung:	Tough shell: Living yeast cells can be simultaneously silica‐encapsulated and thiol‐functionalized by polycondensation of silicic acid and (3‐mercaptopropyl)trimethoxysilane under mild conditions. Various functions such as fluorescent dyes (see picture; green: fluorescein, red: rhodamine), chemical moieties, or proteins, can be introduced to the artificial shell by using maleimide‐based coupling reactions.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201102030