Reversible dementia and gait disturbance after prolonged use of valproic acid

Abstract Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication. Common imaging findings among these reports demonstrate reversible cortical pseudoatrophy and enlargement of the lateral ventricles. This case exemplifies these...

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Veröffentlicht in:Seizure (London, England) England), 2011-07, Vol.20 (6), p.509-511
Hauptverfasser: Evans, Matthew D, Shinar, Ron, Yaari, Roy
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication. Common imaging findings among these reports demonstrate reversible cortical pseudoatrophy and enlargement of the lateral ventricles. This case exemplifies these adverse effects of VPA which can cause reversible neurological symptoms even in long-term treated patients and can present as dementia syndromes such as normal pressure hydrocephalus.
ISSN:1059-1311
1532-2688
DOI:10.1016/j.seizure.2011.02.009