Characterization and Diagnostic Confidence of Contrast-Enhanced Ultrasound for Solid Renal Tumors
Abstract The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens ( n = 24) or magnetic resonance imaging f...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2011-06, Vol.37 (6), p.845-853 |
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| creator | Zhou, Xiang Yan, Feng Luo, Yan Peng, Yu-Lan Parajuly, Shyam Sundar Wen, Xiao-Rong Cai, Di-Ming Li, Yong-Zhong |
| description | Abstract The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens ( n = 24) or magnetic resonance imaging follow-up ( n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2011.02.015 |
| format | Article |
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CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens ( n = 24) or magnetic resonance imaging follow-up ( n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2011.02.015</identifier><identifier>PMID: 21546153</identifier><identifier>CODEN: USMBA3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; AML ; Angiomyolipoma - diagnostic imaging ; Biological and medical sciences ; Carcinoma, Renal Cell - diagnostic imaging ; CEUS ; Contrast Media ; Contrast media. Radiopharmaceuticals ; Diagnosis ; Diagnosis, Differential ; HCC ; Humans ; Kidney Neoplasms - diagnostic imaging ; Kidneys ; Male ; Medical sciences ; Middle Aged ; MRI ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Nephrology. Urinary tract diseases ; Pharmacology. Drug treatments ; Phospholipids ; Radiology ; Renal mass ; Reproducibility of Results ; Sensitivity and Specificity ; Sulfur Hexafluoride ; Tumors ; Tumors of the urinary system ; Ultrasonography - methods ; Ultrasound</subject><ispartof>Ultrasound in medicine & biology, 2011-06, Vol.37 (6), p.845-853</ispartof><rights>World Federation for Ultrasound in Medicine & Biology</rights><rights>2011 World Federation for Ultrasound in Medicine & Biology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-614d54661d9060b8c0575e0555389a71c5c14424be29bf9bfe91c9063d02306d3</citedby><cites>FETCH-LOGICAL-c496t-614d54661d9060b8c0575e0555389a71c5c14424be29bf9bfe91c9063d02306d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2011.02.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24219409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21546153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xiang</creatorcontrib><creatorcontrib>Yan, Feng</creatorcontrib><creatorcontrib>Luo, Yan</creatorcontrib><creatorcontrib>Peng, Yu-Lan</creatorcontrib><creatorcontrib>Parajuly, Shyam Sundar</creatorcontrib><creatorcontrib>Wen, Xiao-Rong</creatorcontrib><creatorcontrib>Cai, Di-Ming</creatorcontrib><creatorcontrib>Li, Yong-Zhong</creatorcontrib><title>Characterization and Diagnostic Confidence of Contrast-Enhanced Ultrasound for Solid Renal Tumors</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Abstract The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens ( n = 24) or magnetic resonance imaging follow-up ( n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%.</description><subject>Adult</subject><subject>Aged</subject><subject>AML</subject><subject>Angiomyolipoma - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - diagnostic imaging</subject><subject>CEUS</subject><subject>Contrast Media</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>HCC</subject><subject>Humans</subject><subject>Kidney Neoplasms - diagnostic imaging</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipids</subject><subject>Radiology</subject><subject>Renal mass</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Sulfur Hexafluoride</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuKFDEQhoMo7rj6CtII4lWPVTl1xwtBZtcDLAjuLngX0knazdjTWZNuYX0an8UnM-2MB7xRCIRUvr-qqL8IeYSwRkD5dLuehymZvPOuC3FNAXENdA0obpEVto2qqcL3t8kKGGAtJFVH5F7OWwBoJGvukiOKgksUbEW6zZVJxk4-hS9mCnGszOiqk2A-jDFPwVabOPbB-dH6KvbfvpbnUnqqT8crU4KuuvzRS5yLrI-pOo9DcNU7P5qhuph3MeX75E5vhuwfHO5jcvny9GLzuj57--rN5sVZbbmSUy2Ru9KVRKdAQtdaEI3wIIRgrTINWmGRc8o7T1XXl-MV2oIyB5SBdOyYPNnnvU7x0-zzpHchWz8MZvRxzrptKLKG0_bfpGxZo5hcyGd70qaYc_K9vk5hZ9KNRtCLGXqr_zRDL2ZooLqYUcQPD2Xmrnz_kv6cfgEeHwCTrRn6VCYa8m-OU1QcVOFO9pwv4_scfNLZhsUSF5K3k3Yx_F8_z_9KY4cwhlL5o7_xeRvnVFzLGnUuAn2-rM-yPYhQsgBn3wHrKsQq</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Zhou, Xiang</creator><creator>Yan, Feng</creator><creator>Luo, Yan</creator><creator>Peng, Yu-Lan</creator><creator>Parajuly, Shyam Sundar</creator><creator>Wen, Xiao-Rong</creator><creator>Cai, Di-Ming</creator><creator>Li, Yong-Zhong</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110601</creationdate><title>Characterization and Diagnostic Confidence of Contrast-Enhanced Ultrasound for Solid Renal Tumors</title><author>Zhou, Xiang ; Yan, Feng ; Luo, Yan ; Peng, Yu-Lan ; Parajuly, Shyam Sundar ; Wen, Xiao-Rong ; Cai, Di-Ming ; Li, Yong-Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-614d54661d9060b8c0575e0555389a71c5c14424be29bf9bfe91c9063d02306d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AML</topic><topic>Angiomyolipoma - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - diagnostic imaging</topic><topic>CEUS</topic><topic>Contrast Media</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>HCC</topic><topic>Humans</topic><topic>Kidney Neoplasms - diagnostic imaging</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipids</topic><topic>Radiology</topic><topic>Renal mass</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Sulfur Hexafluoride</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xiang</creatorcontrib><creatorcontrib>Yan, Feng</creatorcontrib><creatorcontrib>Luo, Yan</creatorcontrib><creatorcontrib>Peng, Yu-Lan</creatorcontrib><creatorcontrib>Parajuly, Shyam Sundar</creatorcontrib><creatorcontrib>Wen, Xiao-Rong</creatorcontrib><creatorcontrib>Cai, Di-Ming</creatorcontrib><creatorcontrib>Li, Yong-Zhong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xiang</au><au>Yan, Feng</au><au>Luo, Yan</au><au>Peng, Yu-Lan</au><au>Parajuly, Shyam Sundar</au><au>Wen, Xiao-Rong</au><au>Cai, Di-Ming</au><au>Li, Yong-Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and Diagnostic Confidence of Contrast-Enhanced Ultrasound for Solid Renal Tumors</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>37</volume><issue>6</issue><spage>845</spage><epage>853</epage><pages>845-853</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><coden>USMBA3</coden><abstract>Abstract The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens ( n = 24) or magnetic resonance imaging follow-up ( n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. 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| subjects | Adult Aged AML Angiomyolipoma - diagnostic imaging Biological and medical sciences Carcinoma, Renal Cell - diagnostic imaging CEUS Contrast Media Contrast media. Radiopharmaceuticals Diagnosis Diagnosis, Differential HCC Humans Kidney Neoplasms - diagnostic imaging Kidneys Male Medical sciences Middle Aged MRI Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Pharmacology. Drug treatments Phospholipids Radiology Renal mass Reproducibility of Results Sensitivity and Specificity Sulfur Hexafluoride Tumors Tumors of the urinary system Ultrasonography - methods Ultrasound |
| title | Characterization and Diagnostic Confidence of Contrast-Enhanced Ultrasound for Solid Renal Tumors |
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