Functional Effect of Platelet Membrane Glycoprotein Ia Gene Polymorphism in the Pathogenesis of Unstable Angina Pectoris

The functional effect of platelet membrane glycoprotein Ia (GPIa) gene 807C/T polymorphism in unstable angina pectoris (UAP) pathogenesis was investigated in Chinese Han individuals. Collagen type I-induced platelet aggregation was measured in 33 healthy subjects. Plasma levels of α-granule membrane protein (GMP-140) were measured in 33 healthy subjects and in 35 patients with recentonset angina at rest within 24 h of hospitalization. Platelet membrane GPIa gene 807C/T polymorphism was determined in all subjects. Lag-time before 30% platelet aggregation was significantly longer in CC genotype than in TC genotype healthy subjects, although there was no significant difference in maximal platelet aggregation between healthy subjects with either genotype. Plasma GMP-140 levels were significantly higher in TC genotype patients compared with CC genotype patients or healthy subjects; a significant difference was also observed between the latter two groups. It was concluded that rapid initiation of collagen-induced platelet aggregation may be associated with the platelet membrane GPIa T807 allele, which may be important in UAP pathogenesis.