The isolation of Corynebacterium coyleae from clinical samples: clinical and microbiological data

Fourteen Corynebacterium coyleae isolates were recovered from 12 in-patients during a 5-years period. In six patients, the isolates were considered as clinically significant, three definite (sepsis), two probable (sepsis and soft tissue infection), and one possible (post-transfusional bacteremia). I...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2008-03, Vol.27 (3), p.177-184
Hauptverfasser: Fernández-Natal, M. I., Sáez-Nieto, J. A., Fernández-Roblas, R., Asencio, M., Valdezate, S., Lapeña, S., Rodríguez-Pollán, R. H., Guerra, J. M., Blanco, J., Cachón, F., Soriano, F.
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Sprache:eng
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Zusammenfassung:Fourteen Corynebacterium coyleae isolates were recovered from 12 in-patients during a 5-years period. In six patients, the isolates were considered as clinically significant, three definite (sepsis), two probable (sepsis and soft tissue infection), and one possible (post-transfusional bacteremia). In the remaining 6 patients (all neonatal bacteremias), there was not enough data for considering the isolates as clinical significant. API Coryne™ identified all isolates as C. jeikeium, while Biolog GP2™ correctly identified 7 out of the 14 isolates. Definitive identification was achieved in all isolates by the sequencing of a fragment of 724 to 1423 pb of 16S rDNA. Successive isolations from two patients presented identical random amplified polymorphic DNA (RAPD) profiles. All of the isolates were in-vitro-sensitive to β-lactams, gentamicin, rifampin, tetracycline, vancomycin, linezolid, and resistant to clindamycin. Resistance to erythromycin occurred in 83.3% of isolates, all of them presenting phenotype cMLS and harboring the gene erm X.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-007-0414-1