Is the number of blood products transfused associated with lower survival in children with acute lymphoblastic leukemia?

Background Blood transfusion during acute lymphoblastic leukemia (ALL) of childhood is scarcely documented. Children with ALL are immunosuppressed by both the disease and its therapy. Transfusion may contribute to the course of ALL through its transfusion‐related immunomodulation (TRIM) effect. Proc...

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Veröffentlicht in:	Pediatric blood & cancer 2011-08, Vol.57 (2), p.217-223
Hauptverfasser:	Jaime-Pérez, José Carlos, Colunga-Pedraza, Perla R., Gómez-Almaguer, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphatic leukemia acute lymphoblastic leukemia Adolescent Age Blood products Blood transfusion Blood Transfusion - methods Cancer Child Child, Preschool Children Chimerism Disease-Free Survival Erythrocytes Humans Immunomodulation Immunosurveillance Infant Infant, Newborn Leukocyte Reduction Procedures leukoreduction microchimerism Multivariate Analysis Platelets Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Proportional Hazards Models Regression analysis Retrospective Studies Survival Survival Analysis Transfusion Reaction transfusion-related immunomodulation
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Zusammenfassung:	Background Blood transfusion during acute lymphoblastic leukemia (ALL) of childhood is scarcely documented. Children with ALL are immunosuppressed by both the disease and its therapy. Transfusion may contribute to the course of ALL through its transfusion‐related immunomodulation (TRIM) effect. Procedure Blood transfusion history and response to therapy for 108 children 5 packed red blood cells (PRBC) remained a significant predictor for death (P = 0.003) and relapse (P = 0.011). For platelets, maximal significance was observed when >30 platelet concentrates (PC) were transfused (P 30 blood products (P
ISSN:	1545-5009 1545-5017 1545-5017
DOI:	10.1002/pbc.22957