An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Brønsted Acid/Pd-Complex-Promoted Tandem Reactions

An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Brønsted Acid/Pd-Complex-Promoted Tandem Reactions

In tandem: A divergent and enantioselective approach to 2,3‐disubstituted indolines was developed through consecutive Brønsted acid/Pd‐complex‐promoted tandem reactions from simple 2‐substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R1=H, F, or Me; R2=alkyl; R3=ar...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry : a European journal 2011-06, Vol.17 (26), p.7193-7197
Hauptverfasser: Duan, Ying, Chen, Mu-Wang, Ye, Zhi-Shi, Wang, Duo-Sheng, Chen, Qing-An, Zhou, Yong-Gui
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
Brønsted acid
Chemistry
hydrogenation
palladium
tandem reaction
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In tandem: A divergent and enantioselective approach to 2,3‐disubstituted indolines was developed through consecutive Brønsted acid/Pd‐complex‐promoted tandem reactions from simple 2‐substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R1=H, F, or Me; R2=alkyl; R3=aryl or alkyl). Three Brønsted acid promoted steps and two Pd‐catalyzed hydrogenation steps were involved in this process.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201100576