Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides

Palladium-Catalyzed Oxidative C–H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides

A palladium-catalyzed oxidative C–H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In the presence of a Pd(TFA)2 catalyst and tert-butylhydroperoxide at 90 °C in general, an array of ortho-acylacetanilides can be afforded in g...

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Veröffentlicht in:Organic letters 2011-06, Vol.13 (12), p.3258-3261
Hauptverfasser: Wu, Yinuo, Li, Baozhu, Mao, Fei, Li, Xingshu, Kwong, Fuk Yee
Format: Artikel
Sprache:eng
Schlagworte:
Acetanilides - chemical synthesis
Acetanilides - chemistry
Aldehydes - chemistry
Catalysis
Molecular Structure
Oxidation-Reduction
Palladium - chemistry
Stereoisomerism
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Zusammenfassung:A palladium-catalyzed oxidative C–H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In the presence of a Pd(TFA)2 catalyst and tert-butylhydroperoxide at 90 °C in general, an array of ortho-acylacetanilides can be afforded in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201201a