Cytotoxic Clerodane Diterpenes from Casearia rupestris

Four new clerodane diterpenes, casearupestrins A−D (1−4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel o...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-04, Vol.74 (4), p.776-781
Hauptverfasser:	Vieira-Júnior, Gerardo M, Dutra, Luiz A, Ferreira, Paulo M. P, de Moraes, Manoel O, Costa Lotufo, Letícia V, Pessoa, Cláudia do Ó, Torres, Roseli Buzanelli, Boralle, Nivaldo, Bolzani, Vanderlan da S, Cavalheiro, Alberto J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Brazil Casearia - chemistry Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology Doxorubicin - pharmacology Drug Screening Assays, Antitumor General pharmacology Humans Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry
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