Cytotoxic Clerodane Diterpenes from Casearia rupestris

Cytotoxic Clerodane Diterpenes from Casearia rupestris

Four new clerodane diterpenes, casearupestrins A−D (1−4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel o...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2011-04, Vol.74 (4), p.776-781
Hauptverfasser: Vieira-Júnior, Gerardo M, Dutra, Luiz A, Ferreira, Paulo M. P, de Moraes, Manoel O, Costa Lotufo, Letícia V, Pessoa, Cláudia do Ó, Torres, Roseli Buzanelli, Boralle, Nivaldo, Bolzani, Vanderlan da S, Cavalheiro, Alberto J
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Brazil
Casearia - chemistry
Diterpenes, Clerodane - chemistry
Diterpenes, Clerodane - isolation & purification
Diterpenes, Clerodane - pharmacology
Doxorubicin - pharmacology
Drug Screening Assays, Antitumor
General pharmacology
Humans
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
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Zusammenfassung:Four new clerodane diterpenes, casearupestrins A−D (1−4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.
ISSN:0163-3864
1520-6025
DOI:10.1021/np100840w