Site-Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations

Making it traceless: A traceless Staudinger reaction between a specifically functionalized sugar phosphine and an azide‐tagged protein allows the construction of well‐defined reverse N‐linked glycoproteins (see scheme). This reaction was applied to different azidoprotein substrates and its potential...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-06, Vol.12 (9), p.1383-1386
Hauptverfasser:	Bernardes, Gonçalo J. L., Linderoth, Lars, Doores, Katie J., Boutureira, Omar, Davis, Benjamin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobutyrates - chemistry Azides - chemistry glycoproteins Glycoproteins - chemical synthesis Glycoproteins - chemistry Molecular Structure Phosphines - chemistry protein modification Proteins - chemistry Staudinger ligation sugar phosphines
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