Site-Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations

Making it traceless: A traceless Staudinger reaction between a specifically functionalized sugar phosphine and an azide‐tagged protein allows the construction of well‐defined reverse N‐linked glycoproteins (see scheme). This reaction was applied to different azidoprotein substrates and its potential...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-06, Vol.12 (9), p.1383-1386
Hauptverfasser:	Bernardes, Gonçalo J. L., Linderoth, Lars, Doores, Katie J., Boutureira, Omar, Davis, Benjamin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobutyrates - chemistry Azides - chemistry glycoproteins Glycoproteins - chemical synthesis Glycoproteins - chemistry Molecular Structure Phosphines - chemistry protein modification Proteins - chemistry Staudinger ligation sugar phosphines
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Beschreibung
Zusammenfassung:	Making it traceless: A traceless Staudinger reaction between a specifically functionalized sugar phosphine and an azide‐tagged protein allows the construction of well‐defined reverse N‐linked glycoproteins (see scheme). This reaction was applied to different azidoprotein substrates and its potentials and limitations are outlined.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201100125