Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity afte...

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Veröffentlicht in:Journal of medicinal chemistry 2011-04, Vol.54 (8), p.3086-3090
Hauptverfasser: Berrade, Luis, Aisa, Bárbara, Ramirez, María J, Galiano, Silvia, Guccione, Salvatore, Moltzau, Lise Román, Levy, Finn Olav, Nicoletti, Ferdinando, Battaglia, Giuseppe, Molinaro, Gemma, Aldana, Ignacio, Monge, Antonio, Perez-Silanes, Silvia
Format: Artikel
Sprache:eng
Schlagworte:
Antidepressive Agents - therapeutic use
Magnetic Resonance Spectroscopy
Spectrophotometry, Infrared
Thiophenes - therapeutic use
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Zusammenfassung:We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm2000773