Integrated profiling of diffuse large B‐cell lymphoma with 7q gain

Summary To characterize diffuse large B‐cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival...

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Veröffentlicht in:	British journal of haematology 2011-05, Vol.153 (4), p.499-503
Hauptverfasser:	Chigrinova, Ekaterina, Mian, Michael, Shen, Yulei, Greiner, Timothy C., Chan, Wing C., Vose, Julie M., Inghirami, Giorgio, Chiappella, Annalisa, Baldini, Luca, Ponzoni, Maurilio, Ferreri, Andrés J. M., Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Facchetti, Fabio, Lazure, Thierry, Lambotte, Olivier, Montes‐Moreno, Santiago, Piris, Miguel A., Zucca, Emanuele, Kwee, Ivo, Bertoni, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Affymetrix Aged aggressive lymphoma Antibodies, Monoclonal, Murine-Derived - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences bone marrow Chromosome Duplication Chromosomes, Human, Pair 7 - genetics Cyclophosphamide - therapeutic use Doxorubicin - therapeutic use Female Follow-Up Studies gain Gene Expression Profiling - methods Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Male Medical sciences MicroRNAs - genetics Middle Aged miRNA Prednisone - therapeutic use Prognosis Rituximab RNA, Neoplasm - genetics Survival Analysis Treatment Outcome Vincristine - therapeutic use
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Zusammenfassung:	Summary To characterize diffuse large B‐cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R‐CHOP. Lesions were inversely associated with bone marrow involvement and number of extra‐nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up‐regulated in 7q+ DLBCL by real‐time PCR.
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2011.08628.x