Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen minipig

Highlights ► Postnatal neurogenesis is important for neuroplasticity and brain repair. ► The Göttingen minipig shares anatomic and physiologic characteristics with humans. ► We examine neurogenesis in the subventricular zone and dentate gyrus of the minipig. ► We find prominent proliferation potency...

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Veröffentlicht in:	Brain research bulletin 2011-05, Vol.85 (3), p.169-179
Hauptverfasser:	Guidi, Sandra, Bianchi, Patrizia, Alstrup, Aage K. Olsen, Henningsen, Kim, Smith, Donald F, Bartesaghi, Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Body Weight Brain Mapping BrdU Bromodeoxyuridine - metabolism Cell Count - methods Cell Differentiation Dentate Gyrus - cytology Dentate Gyrus - growth & development Germinal niches Granule cells Lateral Ventricles - cytology Lateral Ventricles - growth & development Neurogenesis Neurogenesis - physiology Neurology Organ Size Porcine brain Stem Cell Niche - cytology Stem Cell Niche - physiology Stereology Swine Swine, Miniature
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Beschreibung
Zusammenfassung:	Highlights ► Postnatal neurogenesis is important for neuroplasticity and brain repair. ► The Göttingen minipig shares anatomic and physiologic characteristics with humans. ► We examine neurogenesis in the subventricular zone and dentate gyrus of the minipig. ► We find prominent proliferation potency in juvenile as well as adult animals. ► The minipig may be a good model for studying neurogenesis in adult brain disorders.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.03.028