Palladium-Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One-Pot Sequential Suzuki-Miyaura Biaryl Synthesis

Palladium-Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One-Pot Sequential Suzuki-Miyaura Biaryl Synthesis

Top of the one‐pots! The first palladium‐catalyzed borylation of aryl tosylates and mesylates is described. The reaction conditions are mild and provide excellent functional‐group compatibility (e.g., R=CN, CHO, COOMe, C(O)R, NH2, or NH‐indole; see scheme). Pd/MeO‐CM‐phos allows one‐pot sequential r...

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Veröffentlicht in:Chemistry : a European journal 2011-06, Vol.17 (25), p.6913-6917
Hauptverfasser: Chow, Wing Kin, So, Chau Ming, Lau, Chak Po, Kwong, Fuk Yee
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
biaryls
borylation
Chemistry
Compatibility
cross-coupling
Palladium
phosphine
Synthesis
tosylates
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Zusammenfassung:Top of the one‐pots! The first palladium‐catalyzed borylation of aryl tosylates and mesylates is described. The reaction conditions are mild and provide excellent functional‐group compatibility (e.g., R=CN, CHO, COOMe, C(O)R, NH2, or NH‐indole; see scheme). Pd/MeO‐CM‐phos allows one‐pot sequential reactions in the preparation of unsymmetrical biaryls.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201100361