The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate
In this study, the genotoxic effects of sodium benzoate (SB) and potassium benzoate (PB) were investigated in cultured human peripheral lymphocytes using chromosomal aberrations (CA), sister chromatid exchange (SCE), and micronuclei (MN). The level of nuclear DNA damage of SB and PB were also evalua...
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| Veröffentlicht in: | Food and chemical toxicology 2011-04, Vol.49 (4), p.763-769 |
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| creator | Zengin, N. Yüzbaşıoğlu, D. Ünal, F. Yılmaz, S. Aksoy, H. |
| description | In this study, the genotoxic effects of sodium benzoate (SB) and potassium benzoate (PB) were investigated in cultured human peripheral lymphocytes using chromosomal aberrations (CA), sister chromatid exchange (SCE), and micronuclei (MN). The level of nuclear DNA damage of SB and PB were also evaluated using the comet assay. The lymphocytes were incubated with different concentrations of SB (6.25, 12.5, 25, 50, and 100
μg/ml) and PB (62.5, 125, 250, 500, and 1000
μg/ml). A significant increase was observed in CA, SCE, and MN, in almost all treatments compared to negative controls. SB and PB significantly decreased the mitotic index (MI) in all the treatments, compared to the negative controls. However, neither of the additives affected the replication index (RI). Although SB significantly increased DNA damage, PB did not cause a significant increase in DNA damage. The present results indicate that SB and PB are clastogenic, mutagenic and cytotoxic to human lymphocytes
in vitro. |
| doi_str_mv | 10.1016/j.fct.2010.11.040 |
| format | Article |
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μg/ml) and PB (62.5, 125, 250, 500, and 1000
μg/ml). A significant increase was observed in CA, SCE, and MN, in almost all treatments compared to negative controls. SB and PB significantly decreased the mitotic index (MI) in all the treatments, compared to the negative controls. However, neither of the additives affected the replication index (RI). Although SB significantly increased DNA damage, PB did not cause a significant increase in DNA damage. The present results indicate that SB and PB are clastogenic, mutagenic and cytotoxic to human lymphocytes
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μg/ml) and PB (62.5, 125, 250, 500, and 1000
μg/ml). A significant increase was observed in CA, SCE, and MN, in almost all treatments compared to negative controls. SB and PB significantly decreased the mitotic index (MI) in all the treatments, compared to the negative controls. However, neither of the additives affected the replication index (RI). Although SB significantly increased DNA damage, PB did not cause a significant increase in DNA damage. The present results indicate that SB and PB are clastogenic, mutagenic and cytotoxic to human lymphocytes
in vitro.</description><subject>Benzoates - toxicity</subject><subject>Biological and medical sciences</subject><subject>chromosome aberrations</subject><subject>crossing over</subject><subject>cytotoxicity</subject><subject>DNA damage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Food additive</subject><subject>food preservatives</subject><subject>Food Preservatives - toxicity</subject><subject>Food toxicology</subject><subject>Genotoxicity</subject><subject>Human lymphocytes</subject><subject>Humans</subject><subject>lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Medical sciences</subject><subject>mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>nuclear genome</subject><subject>potassium</subject><subject>Potassium benzoate</subject><subject>Sodium benzoate</subject><subject>Sodium Benzoate - toxicity</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EokvLA3CBXBCnbD1O7DhwQlUpSJU4tD1bjj0uXmXjre0sbZ8eL7tAT5ys-fXN-NdHyBugS6AgTldLZ_KS0d0MS9rSZ2QBsmtq0XB4ThaUdbIWPfAj8iqlFaW0g068JEcMoKGSiQWx1z-wwq0eZ519mKrgqlySW5xCDvfe-PzwO_sZKheCrTYRE8ZtgbeYPlZXwfp5XQ04PQadsdJTQULWKT2NT8gLp8eErw_vMbn5cn599rW-_H7x7ezzZW04bXNtHUpbqnNmTEORIwfecuNAiMEaaQZkxhle0q7RjFHmugEd430vBi1c1xyTD_u7mxjuZkxZrX0yOI56wjAnJUUvgYmWFRL2pIkhpYhObaJf6_iggKqdW7VSxa3auVUAqrgtO28P1-dhjfbvxh-ZBXh_AHQyenRRT8anf1zTt1I2O-7dnnM6KH0bC3NzVX7ilELXAoNCfNoTWGxtPUaVjMfJoPURSy0b_H-K_gIi9aGK</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Zengin, N.</creator><creator>Yüzbaşıoğlu, D.</creator><creator>Ünal, F.</creator><creator>Yılmaz, S.</creator><creator>Aksoy, H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110401</creationdate><title>The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate</title><author>Zengin, N. ; Yüzbaşıoğlu, D. ; Ünal, F. ; Yılmaz, S. ; Aksoy, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-dfe8d63552cc30e5e51545cf166bdc8cbe2cfc551573a2202f7bef25996ba6f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Benzoates - toxicity</topic><topic>Biological and medical sciences</topic><topic>chromosome aberrations</topic><topic>crossing over</topic><topic>cytotoxicity</topic><topic>DNA damage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Food additive</topic><topic>food preservatives</topic><topic>Food Preservatives - toxicity</topic><topic>Food toxicology</topic><topic>Genotoxicity</topic><topic>Human lymphocytes</topic><topic>Humans</topic><topic>lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Medical sciences</topic><topic>mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>nuclear genome</topic><topic>potassium</topic><topic>Potassium benzoate</topic><topic>Sodium benzoate</topic><topic>Sodium Benzoate - toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zengin, N.</creatorcontrib><creatorcontrib>Yüzbaşıoğlu, D.</creatorcontrib><creatorcontrib>Ünal, F.</creatorcontrib><creatorcontrib>Yılmaz, S.</creatorcontrib><creatorcontrib>Aksoy, H.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zengin, N.</au><au>Yüzbaşıoğlu, D.</au><au>Ünal, F.</au><au>Yılmaz, S.</au><au>Aksoy, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>49</volume><issue>4</issue><spage>763</spage><epage>769</epage><pages>763-769</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>In this study, the genotoxic effects of sodium benzoate (SB) and potassium benzoate (PB) were investigated in cultured human peripheral lymphocytes using chromosomal aberrations (CA), sister chromatid exchange (SCE), and micronuclei (MN). The level of nuclear DNA damage of SB and PB were also evaluated using the comet assay. The lymphocytes were incubated with different concentrations of SB (6.25, 12.5, 25, 50, and 100
μg/ml) and PB (62.5, 125, 250, 500, and 1000
μg/ml). A significant increase was observed in CA, SCE, and MN, in almost all treatments compared to negative controls. SB and PB significantly decreased the mitotic index (MI) in all the treatments, compared to the negative controls. However, neither of the additives affected the replication index (RI). Although SB significantly increased DNA damage, PB did not cause a significant increase in DNA damage. The present results indicate that SB and PB are clastogenic, mutagenic and cytotoxic to human lymphocytes
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| subjects | Benzoates - toxicity Biological and medical sciences chromosome aberrations crossing over cytotoxicity DNA damage Dose-Response Relationship, Drug Food additive food preservatives Food Preservatives - toxicity Food toxicology Genotoxicity Human lymphocytes Humans lymphocytes Lymphocytes - drug effects Medical sciences mutagenicity Mutagenicity Tests nuclear genome potassium Potassium benzoate Sodium benzoate Sodium Benzoate - toxicity Toxicology |
| title | The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate |
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