Catalytic asymmetric conjugate boration of α,β-unsaturated sulfones

Catalytic asymmetric conjugate boration of α,β-unsaturated sulfones

The α,β-unsaturated sulfones are suitable activated olefins in catalytic asymmetric conjugate β-boration. These substrates undergo smooth conjugate addition of bis(pinacolato)diboron [B(2)(pin)(2)] catalyzed by nonracemic Cu(I)-diphosphine complexes to provide, upon subsequent oxidation, β-hydroxy s...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-06, Vol.47 (23), p.6701-6703
Hauptverfasser: Moure, Abraham L, Arrayás, Ramón Gómez, Carretero, Juan C
Format: Artikel
Sprache:eng
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Zusammenfassung:The α,β-unsaturated sulfones are suitable activated olefins in catalytic asymmetric conjugate β-boration. These substrates undergo smooth conjugate addition of bis(pinacolato)diboron [B(2)(pin)(2)] catalyzed by nonracemic Cu(I)-diphosphine complexes to provide, upon subsequent oxidation, β-hydroxy sulfones in good yields and high enantiocontrol.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc11949d