Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation

The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 μg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplem...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2010-04, Vol.109 (4), p.369-371
Hauptverfasser:	Mu, Wanmeng, Yang, Yu, Jia, Jianghua, Zhang, Tao, Jiang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxyphenyllactic acid 4-Hydroxyphenylpyruvic acid ALIMENT FERMENTE ALIMENTOS FERMENTADOS Antifungal Agents - metabolism Antifungal compound Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS Biotechnology FERMENTACION FERMENTATION FERMENTED FOODS FONGICIDE Food Microbiology FOOD PRESERVATION Fundamental and applied biological sciences. Psychology FUNGICIDAS FUNGICIDES http://www.fao.org/aos/agrovoc#c_25005 http://www.fao.org/aos/agrovoc#c_27521 http://www.fao.org/aos/agrovoc#c_2855 http://www.fao.org/aos/agrovoc#c_3146 http://www.fao.org/aos/agrovoc#c_4144 http://www.fao.org/aos/agrovoc#c_928 Kinetics LACTOBACILLUS Lactobacillus - drug effects Lactobacillus - growth & development Lactobacillus - metabolism Lactobacillus sp. SK007 Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Phenylpropionates - metabolism Phenylpyruvic Acids - metabolism Phenylpyruvic Acids - pharmacology PRESERVACION DE ALIMENTOS PRESERVATION DES ALIMENTS Tyrosine - metabolism Tyrosine - pharmacology
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Zusammenfassung:	The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 μg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplements during fermentation could both increase the HO-4-PLA production yield, and the effect of HO-4-PPA on HO-4-PLA production was remarkably better than that of tyrosine. Using HO-4-PPA as substrate could effectively produce HO-4-PLA, which reached 1.26 mg/ml.
ISSN:	1389-1723 1347-4421
DOI:	10.1016/j.jbiosc.2009.10.005