Orexins and their receptors from fish to mammals: A comparative approach

Research highlights ► Orexins’ are under strong evolutionary pressure to preserve structure and functions. ► OX2R is evolutionary more ancient. ► OX1R likely evolved by gene duplication after the divergence giving rise to mammals. ► Orexins’ are functionally important in regulating physiological pro...

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Veröffentlicht in:	General and comparative endocrinology 2011-04, Vol.171 (2), p.124-130
Hauptverfasser:	Wong, Kari K.Y, Ng, Stephanie Y.L, Lee, Leo T.O, Ng, Hans K.H, Chow, Billy K.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Brain - metabolism endocrinology Endocrinology & Metabolism energy intake energy metabolism Evolution Evolution, Molecular fish Fishes - genetics Fishes - metabolism food intake hypothalamus Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism invertebrates mammals Mammals - genetics Mammals - metabolism Molecular Sequence Data neurons neuropeptides Neuropeptides - chemistry Neuropeptides - genetics Neuropeptides - metabolism Orexin Orexin receptor Orexin Receptors Orexins receptors Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - chemistry Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism reproduction Sequence Homology, Amino Acid sleep
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Zusammenfassung:	Research highlights ► Orexins’ are under strong evolutionary pressure to preserve structure and functions. ► OX2R is evolutionary more ancient. ► OX1R likely evolved by gene duplication after the divergence giving rise to mammals. ► Orexins’ are functionally important in regulating physiological processes
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2011.01.001