Cryptococcal Immune Reconstitution Inflammatory Syndrome after Antiretroviral Therapy in AIDS Patients with Cryptococcal Meningitis: A Prospective Multicenter Study

A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experience...

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Veröffentlicht in:	Clinical infectious diseases 2009-09, Vol.49 (6), p.931-934
Hauptverfasser:	Sungkanuparph, Somnuek, Filler, Scott G., Chetchotisakd, Ploenchan, Pappas, Peter G., Nolen, Tracy L., Manosuthi, Weerawat, Anekthananon, Thanomsak, Morris, Michele I., Supparatpinyo, Khuanchai, Kopetskie, Heather, Kendrick, Amy S., Johnson, Philip C., Sobel, Jack D., Larsen, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - microbiology AIDS AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - complications AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - microbiology Amphotericin B - therapeutic use Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antifungal Agents - therapeutic use Antigens Antigens, Fungal - blood Antiretroviral drugs Antiretroviral Therapy, Highly Active Biological and medical sciences BRIEF REPORTS Cerebrospinal fluid Clinical Trials, Phase II as Topic Cryptococcal meningitis Cryptococcosis Cryptococcus Drug therapy Fluconazole - therapeutic use General aspects Highly active antiretroviral therapy HIV Human mycoses Human viral diseases Humans Immune reconstitution Immune Reconstitution Inflammatory Syndrome - blood Immune Reconstitution Inflammatory Syndrome - complications Immune Reconstitution Inflammatory Syndrome - drug therapy Immune Reconstitution Inflammatory Syndrome - epidemiology Immune system Immunocompromised Host Immunopathology Incidence Infectious diseases Inflammation Kaplan-Meier Estimate Logistic Models Medical sciences Meningitis Meningitis, Cryptococcal - blood Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - drug therapy Meningitis, Cryptococcal - epidemiology Miscellaneous mycoses Mortality Mycoses Predisposing factors Proportional Hazards Models Prospective Studies Randomized Controlled Trials as Topic Risk Factors Statistical median Time Factors Tuberculosis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/605497