Exocytosis of Mesoporous Silica Nanoparticles from Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting

The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-06, Vol.7 (11), p.1526-1532
Hauptverfasser:	Slowing, Igor I., Vivero-Escoto, Juan L., Zhao, Yannan, Kandel, Kapil, Peeraphatdit, Chorthip, Trewyn, Brian G., Lin, Victor S.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Endothelial Cells - cytology Endothelial Cells - metabolism enhanced permeability and retention Exocytosis Flow Cytometry Fluorescein-5-isothiocyanate - metabolism Fluorescence HeLa Cells Humans Intracellular Space - metabolism Magnetics mesoporous silica nanoparticles Microscopy, Confocal Nanoparticles - chemistry Nanoparticles - ultrastructure Nanotechnology - methods Porosity protein sequestration Proteins - metabolism Silicon Dioxide - metabolism Umbilical Veins - cytology
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Zusammenfassung:	The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The exocytosis of highly adsorbent magnetic MSNs proves to be useful as a means for harvesting biomolecules from living cells.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201002077