Inflammasome activation and IL-1β and IL-18 processing during infection

Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inact...

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Veröffentlicht in:	Trends in immunology 2011-03, Vol.32 (3), p.110-116
Hauptverfasser:	van de Veerdonk, Frank L, Netea, Mihai G, Dinarello, Charles A, Joosten, Leo A.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals antimicrobial properties caspase-1 cytotoxicity Humans immune response Infection - immunology Inflammation - immunology interleukin-18 Interleukin-18 - immunology interleukin-1beta Interleukin-1beta - immunology Interleukin-1beta - secretion phagocytes serine proteinases T-lymphocytes T-Lymphocytes - immunology T-Lymphocytes - secretion
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Beschreibung
Zusammenfassung:	Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of IL-1β and IL-18 into bioactive cytokines. In this review, we discuss the controversies regarding inflammasome activation and the role of the inflammasome during infection. We highlight alternative mechanisms for processing IL-1β and IL-18 during infection, which involve extracellular cleavage of the inactive cytokines by neutrophil-derived serine proteases or proteases released from cytotoxic T cells.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2011.01.003