A chemoenzymatic synthesis of 5a-carba-α- d-mannose-6-phosphate

An efficient chemical synthesis of 5a-carba-α- d-mannose and its enzymatic elaboration to 5a-carba-α- d-mannose-6-phosphate, using yeast hexokinase, is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Carbohydrate research 2011-07, Vol.346 (10), p.1257-1261
Hauptverfasser:	Williams, Paula M., Sheldrake, Gary N., Macdonald, Simon J.F., Hamilton, Chris J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Carba sugar Hexokinase Hexokinase - chemistry Mannosephosphates - chemical synthesis Mannosephosphates - chemistry Models, Chemical Pseudo-sugar Saccharomyces cerevisiae - enzymology synthesis Trisaccharides - chemical synthesis Trisaccharides - chemistry yeasts
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Beschreibung
Zusammenfassung:	An efficient chemical synthesis of 5a-carba-α- d-mannose and its enzymatic elaboration to 5a-carba-α- d-mannose-6-phosphate, using yeast hexokinase, is described.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/j.carres.2011.04.011