New angucycline C-glycosides from Streptomyces sp. RI33

In the course of our screening program for anticancer agents from natural sources, five new angucyclines, JBIR-90 ( 1 ), -116 ( 2 ), -91 ( 3 ), -92 ( 4 ) and -93 ( 5 ), were isolated from the fermentation broth of Streptomyces sp. RI33. The structures of 1 – 5 were elucidated on the basis of 1D and...

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Veröffentlicht in:	Journal of antibiotics 2011-05, Vol.64 (5), p.367-372
Hauptverfasser:	Ueda, Jun-ya, Izumikawa, Miho, Mukai, Akira, Nagai, Aya, Hwang, Ji-Hwan, Takagi, Motoki, Shin-ya, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2258 631/326/41 631/92/349 692/699/67/1641 Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Fermentation Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans Inhibitory Concentration 50 Life Sciences Magnetic Resonance Spectroscopy Mass Spectrometry Medicinal Chemistry Mesothelioma Mesothelioma - drug therapy Mesothelioma - pathology Microbiology Organic Chemistry original-article Pleural Neoplasms - drug therapy Pleural Neoplasms - pathology Streptomyces - metabolism
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Zusammenfassung:	In the course of our screening program for anticancer agents from natural sources, five new angucyclines, JBIR-90 ( 1 ), -116 ( 2 ), -91 ( 3 ), -92 ( 4 ) and -93 ( 5 ), were isolated from the fermentation broth of Streptomyces sp. RI33. The structures of 1 – 5 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 2 – 4 showed cytotoxic activities against malignant pleural mesothelioma cells at IC 50 values of 20–50 μ M .
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2011.8