Role of biomarkers in assessment of early infarct size after successful p-PCI for STEMI

Objective The aim of the study was to find out if single time point and estimated cumulative release of cardiac troponin T (cTnT) and creatine kinase (CK) correlate with early infarct size and left ventricular function measured by cardiac magnetic resonance (CMR). Methods CMR and serial CK and cTnT measurements were performed in 103 patients (85 male, mean age 55.8 ± 12.1 years) within at least 8 days (3.1 ± 1.5 days) after first acute myocardial infarction and successful primary percutaneous coronary interventions. Infarct size was determined on delayed gadolinium-enhanced phase-sensitive IR-SSFP CMR sequences. Single time point, peak and cumulative cardiac protein release were correlated with infarct size. Results All single time point, peak and estimated cumulative release of CK and cTnT values except on admission showed significant correlations with infarct size. Among single time point values, cTnT after 96 h (cTnT 96 ; r = 0.680, p