Serum osteoprotegerin, RANKL and fibroblast growth factor-23 in children with chronic kidney disease

Osteoprotegerin (OPG), receptor activator of the nuclear factor κB ligand (RANKL) and fibroblast growth factor-23 (FGF-23) play a central role in renal osteodystrophy. We evaluated OPG/RANKL and FGF-23 levels in 51 children with chronic kidney disease (CKD) [ n = 26 stage 3 or 4 (CKD3–4) and n = 2...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2011-07, Vol.26 (7), p.1105-1114
Hauptverfasser:	Siomou, Ekaterini, Challa, Anna, Printza, Nikoleta, Giapros, Vasileios, Petropoulou, Fotini, Mitsioni, Andromachi, Papachristou, Fotios, Stefanidis, Constantinos J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - blood Analysis of Variance Biomarkers - blood Bone diseases Bone Remodeling Calcification Case-Control Studies Child Child, Preschool Chronic Disease Chronic kidney failure Cytokine receptors Development and progression Endocrine system Female Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblasts Gene expression Greece Growth factors Health aspects Humans Isoenzymes - blood Kidney diseases Kidney Diseases - blood Kidney Diseases - diagnosis Kidney Diseases - physiopathology Ligands Male Medicine & Public Health Membrane proteins Metabolism Nephrology Original Article Osteoprotegerin - blood Parathyroid Hormone - blood Pathogenesis Pediatric research Pediatrics Phosphates Phosphates - blood RANK Ligand - blood Regression Analysis Severity of Illness Index Tartrate-Resistant Acid Phosphatase Tumor necrosis factor-TNF Urology
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Zusammenfassung:	Osteoprotegerin (OPG), receptor activator of the nuclear factor κB ligand (RANKL) and fibroblast growth factor-23 (FGF-23) play a central role in renal osteodystrophy. We evaluated OPG/RANKL and FGF-23 levels in 51 children with chronic kidney disease (CKD) [ n = 26 stage 3 or 4 (CKD3–4) and n = 25 stage 5 (CKD5)] and 61 controls. Any possible association with intact parathyroid hormone (iPTH) and bone turnover markers was also investigated. The OPG levels were lower in the CKD3–4 group ( p
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s00467-011-1870-5