Transcription and RNAi in heterochromatic gene silencing

Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and funct...

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Veröffentlicht in:	Nature structural & molecular biology 2007-11, Vol.14 (11), p.1041-1048
Hauptverfasser:	Bühler, Marc, Moazed, Danesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Chromatin Deoxyribonucleic acid DNA Eukaryota - genetics Gene silencing Genetic transcription Heterochromatin - chemistry Heterochromatin - genetics Heterochromatin - metabolism Life Sciences Membrane Biology Models, Genetic Molecular biology Molecular structure Physiological aspects Protein Structure review-article Ribonucleic acid RNA RNA - metabolism RNA - physiology RNA Interference - physiology RNA, Small Interfering - metabolism RNA, Small Interfering - physiology Schizosaccharomyces pombe Transcription, Genetic - physiology Yeasts
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