Transcription and RNAi in heterochromatic gene silencing

Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and funct...

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Veröffentlicht in:	Nature structural & molecular biology 2007-11, Vol.14 (11), p.1041-1048
Hauptverfasser:	Moazed, Danesh, Bühler, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Chromatin Deoxyribonucleic acid DNA Eukaryota - genetics Gene silencing Genetic transcription Heterochromatin - chemistry Heterochromatin - genetics Heterochromatin - metabolism Life Sciences Membrane Biology Models, Genetic Molecular biology Molecular structure Physiological aspects Protein Structure review-article Ribonucleic acid RNA RNA - metabolism RNA - physiology RNA Interference - physiology RNA, Small Interfering - metabolism RNA, Small Interfering - physiology Schizosaccharomyces pombe Transcription, Genetic - physiology Yeasts
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Beschreibung
Zusammenfassung:	Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and function of heterochromatin. In this review, we discuss the roles of RNA and RNA turnover in mechanisms that mediate heterochromatin assembly and keep heterochromatic domains silent.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/nsmb1315