Evaluation of oxidative stress and anti-oxidant status in rat serum following exposure of carbon nanotubes

The aim of the present study was to evaluate the oxidative stress and anti-oxidant status in rat serum following intra-tracheal instillation of multi wall carbon nanotubes (MWCNT). The lungs of rats were intra-tracheally instilled with (single dose of) Phosphate-buffered saline (PBS)+1% of Tween 80...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2011-03, Vol.59 (2), p.251-257
Hauptverfasser:	Reddy, A. Rama Narsimha, Rao, M. Venkateswar, Krishna, Devarakonda R., Himabindu, V., Reddy, Y. Narsimha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Carbon nanotubes Catalase Catalase - metabolism Glutathione Glutathione - metabolism Inhalation Exposure - adverse effects Lipid Peroxidation - drug effects Lung - drug effects Male MDA MWCNT Nanotubes, Carbon - toxicity Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Superoxide Dismutase - blood
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Zusammenfassung:	The aim of the present study was to evaluate the oxidative stress and anti-oxidant status in rat serum following intra-tracheal instillation of multi wall carbon nanotubes (MWCNT). The lungs of rats were intra-tracheally instilled with (single dose of) Phosphate-buffered saline (PBS)+1% of Tween 80 (Solvent Control) or MWCNT or carbonyl Iron (negative control) or quartz particles (positive control) at a dose of 0.2, 1 and 5mg/kg body weight. Following exposure, the blood samples were collected at 1, 7, 30 and 90days of post instillation of nanoparticles and different parameters were estimated to assess the oxidative stress induced by the instillation of MWCNT. Exposure of MWCNT to rats produced a significant (p
ISSN:	0273-2300 1096-0295
DOI:	10.1016/j.yrtph.2010.10.007