SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups

Abstract Background and aims Intense research has been performed to identify the genetic risk factors in type 2 diabetes, and a single nucleotide polymorphism (SNP) in SLC30A8 (rs13266634) was reported to be associated with type 2 diabetes mellitus. However, published data on the association between SLC30A8 polymorphism and the risk of type 2 diabetes were inconsistent. Therefore, we conducted this meta-analysis to derive a more precise estimation of the relationship. Methods and results We searched PubMed through October 2009 to identify all relevant papers. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted under an additive genetic model. In the current meta-analysis, we identified a total of 27 groups including 42,609 cases and 69,564 controls. In analyses of the case–control studies by ethnicity, the results indicated that SLC30A8 polymorphism was related to elevate risks of type 2 diabetes both in Europeans (OR = 1.15, 95% CI 1.11–1.18, P < 0.001) and Asians (OR = 1.15, 95% CI 1.11–1.19, P < 0.001). Next, we separated hospital-based case–control studies from population-based case–control studies, however, there was no apparent difference between population-based case–control study groups (OR = 1.15, 95% CI 1.12–1.17, P < 0.001) and hospital-based case–control study groups (OR = 1.16, 95% CI 1.07–1.25, P < 0.001). Conclusion Our present meta-analysis provided evidence that SLC30A8 (rs13266634) C allele carriers could elevate the risk of type 2 diabetes, especially in Europeans and Asians.