Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock

Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock

Severe sepsis is frequently associated with microcirculatory abnormalities despite seemingly adequate hemodynamic resuscitation. As increased serum angiotensin II levels may play a role in this dysfunction, we evaluated the microcirculatory effects of enalaprilat in an experimental model of septic s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Shock (Augusta, Ga.) Ga.), 2011-06, Vol.35 (6), p.542-549
Hauptverfasser: Salgado, Diamantino Ribeiro, He, Xinrong, Su, Fuhong, de Sousa, Dalton Barros, Penaccini, Laura, Maciel, Leonardo Kfuri, Taccone, Fabio, Rocco, José Rodolfo, Silva, Eliézer, De Backer, Daniel, Vincent, Jean-Louis
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin II - antagonists & inhibitors
Animals
Enalaprilat - therapeutic use
Female
Fluid Therapy
Microcirculation - drug effects
Mouth Floor - blood supply
Placebos
Random Allocation
Sheep, Domestic
Shock, Septic - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Severe sepsis is frequently associated with microcirculatory abnormalities despite seemingly adequate hemodynamic resuscitation. As increased serum angiotensin II levels may play a role in this dysfunction, we evaluated the microcirculatory effects of enalaprilat in an experimental model of septic shock. One hour after injection of 1.5 g/kg body weight of feces into the abdominal cavity, 16 adult female anesthetized, mechanically ventilated sheep were randomized to receive 2.5 mg enalaprilat or saline. When fluid-resistant hypotension (mean arterial pressure,
ISSN:1073-2322
1540-0514
DOI:10.1097/SHK.0b013e3182115e6a