Increase in Ceramide Level after Application of Various Sizes of Sphingomyelin Liposomes to a Cultured Human Skin Model

Increase in Ceramide Level after Application of Various Sizes of Sphingomyelin Liposomes to a Cultured Human Skin Model

Sphingomyelin-based liposomes (SPM-L) that were sized (or not) by extrusion through a filter with pores of 100, 200, or 400 nm were applied to a three-dimensional cultured human skin model in order to evaluate which size of SPM-L was most effective at increasing its ceramide level. The diameters of...

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Veröffentlicht in:Skin pharmacology and physiology 2011-01, Vol.24 (4), p.218-223
Hauptverfasser: Tokudome, Y., Jinno, M., Todo, H., Kon, T., Sugibayashi, K., Hashimoto, F.
Format: Artikel
Sprache:eng
Schlagworte:
Ceramides - metabolism
Humans
Liposomes - administration & dosage
Original Paper
Particle Size
Skin - drug effects
Skin - metabolism
Sphingomyelins - administration & dosage
Tissue Culture Techniques
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Zusammenfassung:Sphingomyelin-based liposomes (SPM-L) that were sized (or not) by extrusion through a filter with pores of 100, 200, or 400 nm were applied to a three-dimensional cultured human skin model in order to evaluate which size of SPM-L was most effective at increasing its ceramide level. The diameters of the SPM-L in PBS were 102.7, 181.0, 224.0, and 380.1 nm. The diameters of the liposomes in the culture medium were 117.5, 199.2, 242.1, and 749.8 nm. The diameter of the small liposomes (
ISSN:1660-5527
1660-5535
DOI:10.1159/000324886