Are GSTM1, GSTT1 and CAG Repeat Length of Androgen Receptor Gene Polymorphisms Associated with Risk of Prostate Cancer in Iranian Patients?

We conducted this study to investigate whether CAG repeat length in androgen receptor gene and GSTM1 and GSTT1 polymorphisms influence prostate cancer risk in Iranian newly diagnosed cancer patients compared to age-matched BPH group and healthy individuals. DNA from 110 pathologically-confirmed pros...

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Veröffentlicht in:	Pathology oncology research 2011-06, Vol.17 (2), p.269-275
Hauptverfasser:	Ashtiani, Zahra Ousati, Hasheminasab, Sayed-Mohammad, Ayati, Mohsen, Goulian, Bareto Sabah, Modarressi, Mohammad Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Androgen receptors Biomedical and Life Sciences Biomedicine Cancer Research Genetic Predisposition to Disease Genotype Glutathione Transferase - genetics Humans Immunology Iran Male Middle Aged Oncology Pathology Polymorphism, Single Nucleotide Prostatic Hyperplasia - genetics Prostatic Neoplasms - genetics Receptors, Androgen - genetics Reverse Transcriptase Polymerase Chain Reaction Risk Factors Trinucleotide Repeats
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Zusammenfassung:	We conducted this study to investigate whether CAG repeat length in androgen receptor gene and GSTM1 and GSTT1 polymorphisms influence prostate cancer risk in Iranian newly diagnosed cancer patients compared to age-matched BPH group and healthy individuals. DNA from 110 pathologically-confirmed prostate cancer patients, 99 age-matched men with Benign Prostatic Hyperplasia (BPH) and 100 healthy individuals were extracted and amplified by polymerase chain reaction (PCR). PCR products were examined by electrophoresis and sequencing. The mean number of CAG repeat in prostate cancer patients was significantly smaller than normal (19.9 vs 22.8; p
ISSN:	1219-4956 1532-2807
DOI:	10.1007/s12253-010-9309-z