Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Tertiary Grignard Reagents Utilizing Donor-Functionalized N-Heterocyclic Carbenes (NHCs)

Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Tertiary Grignard Reagents Utilizing Donor-Functionalized N-Heterocyclic Carbenes (NHCs)

One, two or three? The utilization of sterically hindered alkyl substrates represents a major challenge of the present cross‐coupling methodology. The nickel‐catalyzed Kumada cross‐ coupling of tertiary alkyl Grignard reagents with aryl bromides allows this difficult reaction with numerous different...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry : a European journal 2011-05, Vol.17 (22), p.6052-6055
Hauptverfasser: Lohre, Claudia, Dröge, Thomas, Wang, Congyang, Glorius, Frank
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
aryl bromides
Bromides
Carbenes
Chemistry
Cross coupling
Grignard reagents
Ligands
N-heterocyclic carbenes
Nickel
Reagents
Substrates
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:One, two or three? The utilization of sterically hindered alkyl substrates represents a major challenge of the present cross‐coupling methodology. The nickel‐catalyzed Kumada cross‐ coupling of tertiary alkyl Grignard reagents with aryl bromides allows this difficult reaction with numerous different substrates. Optimal results were obtained using sterically demanding, bifunctional N‐heterocyclic carbene ligands.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201100909