Versatile synthesis of α-substituted taurines from nitroolefins

Versatile synthesis of α-substituted taurines from nitroolefins

A series of 1-substituted and 1,1-disubstituted taurines were synthesized from nitroolefins via the Michael addition with sodium ethylxanthate, oxidation with performic acid, and reduction with hydrogen in the presence of palladium on carbon powder. The current route is a versatile and salt-free met...

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Veröffentlicht in:Amino acids 2011-06, Vol.41 (1), p.195-203
Hauptverfasser: Xu, Chuanxiang, Xu, Jiaxi
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Alkenes - chemistry
Amino acids
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Carbon
hydrogen
Life Sciences
Molecular Structure
Neurobiology
Nitroparaffins - chemistry
Original Article
Oxidation
Palladium
Proteomics
Reduction
Sodium
Synthesis
Taurine - analogs & derivatives
Taurine - chemical synthesis
Taurine - chemistry
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Zusammenfassung:A series of 1-substituted and 1,1-disubstituted taurines were synthesized from nitroolefins via the Michael addition with sodium ethylxanthate, oxidation with performic acid, and reduction with hydrogen in the presence of palladium on carbon powder. The current route is a versatile and salt-free method for synthesis of both aliphatic and aromatic 1-substituted and 1,1-disubstituted taurines.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-010-0655-7