InCl3/Me3SiBr-Catalyzed Direct Coupling between Silyl Ethers and Enol Acetates

InCl3/Me3SiBr-Catalyzed Direct Coupling between Silyl Ethers and Enol Acetates

A combined Lewis acid catalyst of InCl3 and Me3SiBr promoted the direct use of enol acetates in the coupling with low-reactive silyl ethers, in which functional groups including ketones and aldehydes survived. Sterically hindered silyl ethers such as ROSiEt3, ROSiPh3, ROSit-BuMe2, and ROSii-Pr3 were...

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Veröffentlicht in:Organic letters 2011-05, Vol.13 (10), p.2762-2765
Hauptverfasser: Onishi, Yoshiharu, Nishimoto, Yoshihiro, Yasuda, Makoto, Baba, Akio
Format: Artikel
Sprache:eng
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Zusammenfassung:A combined Lewis acid catalyst of InCl3 and Me3SiBr promoted the direct use of enol acetates in the coupling with low-reactive silyl ethers, in which functional groups including ketones and aldehydes survived. Sterically hindered silyl ethers such as ROSiEt3, ROSiPh3, ROSit-BuMe2, and ROSii-Pr3 were also applicable.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200875m