Nucleophilic Deoxyfluorination of Catechols

Nucleophilic deoxyfluorinaiton of one of the two hydroxyl groups of catechols has been developed via the Umpolung concept. This method was successively applied to naturally occurring catechols, such as catechins and dopamine, to produce novel fluorinated analogues.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2011-05, Vol.13 (10), p.2714-2717
Hauptverfasser:	Nemoto, Hiroyuki, Nishiyama, Tsuyoshi, Akai, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catechin - chemistry Catechols - chemistry Dopamine - chemistry Hydrocarbons, Fluorinated - chemical synthesis Hydrocarbons, Fluorinated - chemistry Molecular Structure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Nucleophilic deoxyfluorinaiton of one of the two hydroxyl groups of catechols has been developed via the Umpolung concept. This method was successively applied to naturally occurring catechols, such as catechins and dopamine, to produce novel fluorinated analogues.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol200808q