You can't have your cake and eat it too

Fluorescence in-situ hybridisation (FISH) studies using a dual fusion probe looking for the characteristic IGH/MYC gene rearrangement associated with Burkitt lymphoma, posthumously confirmed rearrangement in 50/55 interphase nuclei examined ( Figure 1 , below). Ki-67 staining as a marker of dividing cells and by definition, is >99% positive in Burkitt lymphoma. 4 5 Immunophenotyping classically reveals a clonal B cell phenotype with surface IgM, Bcl-6, CD19, CD20, CD22, CD10, and CD79a, and are negative for CD5, CD23, and TdT. 5 Burkitt lymphoma is caused by characteristic chromosomal translocations occurring between chromosome 8 (band q24, the c-myc gene, responsible for cell cycle regulation-seen as the red signal in figure 1 ) and one of the immunoglobulin (Ig) gene-containing chromosomes, most frequently chromosome 14 (band q32, IgH gene-seen as the green signal in figure 1 , below) as in our case or alternatively chromosomes 2 (band p12, Ig κ) or 22 (band q11, Ig λ).