Nickel-Catalyzed Cross-Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents

Nickel-Catalyzed Cross-Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents

Broad scope and good tolerance: An efficient cross‐coupling of aryltrimethylammonium iodide salts with aryl‐, methyl‐, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the CN bond and displays broad substrate scope and good funct...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-05, Vol.50 (21), p.4901-4904
Hauptverfasser: Xie, Lan-Gui, Wang, Zhong-Xia
Format: Artikel
Sprache:eng
Schlagworte:
cross-coupling
CN activation
homogeneous catalysis
nickel
organozinc reagents
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Zusammenfassung:Broad scope and good tolerance: An efficient cross‐coupling of aryltrimethylammonium iodide salts with aryl‐, methyl‐, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the CN bond and displays broad substrate scope and good functional group tolerance. NMP=N‐methylpyrrolidine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201100683