Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

Oligodendrocyte differentiation-stimulating effect of compound 5. We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of ol...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2011-05, Vol.19 (10), p.3255-3264
Hauptverfasser:	Sakuma, Shogo, Endo, Tsuyoshi, Kanda, Takashi, Nakamura, Hideki, Yamasaki, Satomi, Yamakawa, Tomio
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals Benzisoxazole ring Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cell Differentiation - drug effects Cell Line Cells, Cultured Cerebral Cortex - cytology chemistry drugs Humans Isoxazoles - chemistry Isoxazoles - pharmacology Medical sciences Multiple sclerosis Oligodendrocyte precursor cells Oligodendroglia - cytology Oligodendroglia - drug effects Pharmacology. Drug treatments PPAR delta - agonists PPAR delta - metabolism PPARδ agonist Rats Rats, Wistar sclerosis transcriptional activation
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