Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

Oligodendrocyte differentiation-stimulating effect of compound 5. We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of ol...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2011-05, Vol.19 (10), p.3255-3264
Hauptverfasser:	Sakuma, Shogo, Endo, Tsuyoshi, Kanda, Takashi, Nakamura, Hideki, Yamasaki, Satomi, Yamakawa, Tomio
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals Benzisoxazole ring Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cell Differentiation - drug effects Cell Line Cells, Cultured Cerebral Cortex - cytology chemistry drugs Humans Isoxazoles - chemistry Isoxazoles - pharmacology Medical sciences Multiple sclerosis Oligodendrocyte precursor cells Oligodendroglia - cytology Oligodendroglia - drug effects Pharmacology. Drug treatments PPAR delta - agonists PPAR delta - metabolism PPARδ agonist Rats Rats, Wistar sclerosis transcriptional activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Oligodendrocyte differentiation-stimulating effect of compound 5. We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2011.03.053