Malaria: Surprising Mechanism of Merozoite Egress Revealed

A recent study reveals that the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum ends with the ruptured erythrocyte membrane curling outwards, buckling, everting and vesiculating. Analogy with the sequence seen during spontaneous inside-out vesiculation of erythrocyte membranes...

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Veröffentlicht in:	Current biology 2011-05, Vol.21 (9), p.R314-R316
1. Verfasser:	Lew, Virgilio L.
Format:	Artikel
Sprache:	eng
Schlagworte:	asexual reproduction cytoskeleton Erythrocyte Membrane - parasitology Erythrocyte Membrane - physiology Erythrocyte Membrane - ultrastructure erythrocytes Erythrocytes - parasitology Humans malaria Malaria - physiopathology merozoites Merozoites - physiology Models, Biological parasites Plasmodium falciparum Plasmodium falciparum - physiology Reproduction, Asexual - physiology
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Beschreibung
Zusammenfassung:	A recent study reveals that the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum ends with the ruptured erythrocyte membrane curling outwards, buckling, everting and vesiculating. Analogy with the sequence seen during spontaneous inside-out vesiculation of erythrocyte membranes suggests that the parasite co-opts pre-existing cytoskeletal conformations to facilitate terminal merozoite dispersal.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2011.03.066