[CuBr(PPh3)3] for Azide−Alkyne Cycloaddition Reactions under Strict Click Conditions

[CuBr(PPh3)3] for Azide−Alkyne Cycloaddition Reactions under Strict Click Conditions

A careful methodological study revealed a true Click catalytic system based on commercially available [CuBr(PPh3)3]. This system is active at room temperature, with 0.5 mol % [Cu] (or less), in the absence of any additive, and it does not require any purification step to isolate pure triazoles.

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Veröffentlicht in:Journal of organic chemistry 2011-04, Vol.76 (7), p.2367-2373
Hauptverfasser: Lal, Steven, Díez-González, Silvia
Format: Artikel
Sprache:eng
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Zusammenfassung:A careful methodological study revealed a true Click catalytic system based on commercially available [CuBr(PPh3)3]. This system is active at room temperature, with 0.5 mol % [Cu] (or less), in the absence of any additive, and it does not require any purification step to isolate pure triazoles.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo200085j