Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Recently, the coffee constituents 5‐O‐caffeoylquinic acid (CGA) and N‐methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant‐response element (ARE) detoxifying pathway under cell‐culture condition. To study the impact of CGA and NMP on the Nrf2‐activating properties of a complex...

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Veröffentlicht in:	Molecular nutrition & food research 2011-05, Vol.55 (5), p.798-802
Hauptverfasser:	Boettler, Ute, Volz, Nadine, Pahlke, Gudrun, Teller, Nicole, Kotyczka, Christine, Somoza, Veronika, Stiebitz, Herbert, Bytof, Gerhard, Lantz, Ingo, Lang, Roman, Hofmann, Thomas, Marko, Doris
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Antioxidative Biological and medical sciences Chemoprevention Chlorogenic Acid - pharmacology Coffee Coffee - chemistry Coffee, tea and other stimulative beverage industries Enzyme Induction - drug effects Food industries Fundamental and applied biological sciences. Psychology Gene transcription Glutamate-Cysteine Ligase - biosynthesis Heme Oxygenase-1 - biosynthesis HT29 Cells Humans NF-E2-Related Factor 2 - physiology Nrf2 pathway Pyridinium Compounds - pharmacology Reactive Oxygen Species - metabolism Response Elements - physiology
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