A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl‐CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2011-05, Vol.50 (20), p.4667-4670
Hauptverfasser: Xu, Zhongli, Ding, Ling, Hertweck, Christian
Format: Artikel
Sprache:eng
Schlagworte:
combinatorial biosynthesis
divergolides
extender units
germicidins
Macrolides - chemistry
Macrolides - metabolism
Molecular Conformation
polyketides
Stereoisomerism
Streptomyces - chemistry
Streptomyces - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Sharing a branch: The first biosynthesis of an unprecedented branched PKS extender unit from valine/isobutyrate was unveiled, involving a designated ketosynthase III and a crotonyl reductase/carboxylase (CCR). Isobutylmalonyl‐CoA (ibMCoA) is not only employed in divergolide biosynthesis but is also incorporated into novel, antibacterial germicidins (see scheme). Such natural biocombinatorics are unparalleled in polyketide biosynthesis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201008265